TMF/ARA160 - A Novel Mediator of Androgen Receptor Degradation in Hypoxic prostate carcinoma cells
Professor Uri Nir, Faculty of Life Sciences, Bar-Ilan University , Israel

Hypoxia is a prevalent stress in solid tumours, occurring when malignant cells outgrow the carrying capacity of the local vasculature.

We have identified a Golgi resident ‘BC box' containing protein-TMF/ARA160, whose level is down-regulated in prostate tumors in vivo . TMF/ARA160 is dispersed in the cytoplasm of hypoxic prostate carcinoma cells, thereafter recruiting the androgen receptor (AR) to ubiquitination and proteasomal degredation. In the current application we propose to unravel the cellular and molecular factors that regulate the activity of TMF/ARA160. This study will open new ways for prostate cancer intervention, by manipulating the level of the AR.

Project commenced
June 2005

Length of project
2 years

Amount Supported
£40,000